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1lx5

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{{Seed}}
 
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[[Image:1lx5.png|left|200px]]
 
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==Crystal Structure of the BMP7/ActRII Extracellular Domain Complex==
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The line below this paragraph, containing "STRUCTURE_1lx5", creates the "Structure Box" on the page.
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<StructureSection load='1lx5' size='340' side='right'caption='[[1lx5]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LX5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1lx5| PDB=1lx5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lx5 OCA], [https://pdbe.org/1lx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lx5 RCSB], [https://www.ebi.ac.uk/pdbsum/1lx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lx5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BMP7_HUMAN BMP7_HUMAN] Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/1lx5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lx5 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the BMP7/ActRII Extracellular Domain Complex===
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==See Also==
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12667445}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12667445 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12667445}}
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==About this Structure==
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1LX5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX5 OCA].
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==Reference==
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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly., Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S, Mol Cell. 2003 Mar;11(3):605-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12667445 12667445]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Choe S]]
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[[Category: Choe, S.]]
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[[Category: Greenwald J]]
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[[Category: Greenwald, J.]]
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[[Category: Groppe J]]
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[[Category: Groppe, J.]]
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[[Category: Kwiatkowski W]]
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[[Category: Kwiatkowski, W.]]
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[[Category: Ligand-receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:44:30 2008''
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Current revision

Crystal Structure of the BMP7/ActRII Extracellular Domain Complex

PDB ID 1lx5

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