This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1m1x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:30, 10 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1m1x.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+==
-
The line below this paragraph, containing "STRUCTURE_1m1x", creates the "Structure Box" on the page.
+
<StructureSection load='1m1x' size='340' side='right'caption='[[1m1x]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1m1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1X FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-
{{STRUCTURE_1m1x| PDB=1m1x | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1x OCA], [https://pdbe.org/1m1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1x RCSB], [https://www.ebi.ac.uk/pdbsum/1m1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1x ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1x_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1x ConSurf].
 +
<div style="clear:both"></div>
-
===CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+===
+
==See Also==
-
 
+
*[[Integrin 3D structures|Integrin 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11884718}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 11884718 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_11884718}}
+
-
 
+
-
==About this Structure==
+
-
1M1X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1X OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand., Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA, Science. 2002 Apr 5;296(5565):151-5. Epub 2002 Mar 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11884718 11884718]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Arnaout, M A.]]
+
[[Category: Arnaout MA]]
-
[[Category: Frech, M.]]
+
[[Category: Frech M]]
-
[[Category: Goodman, S L.]]
+
[[Category: Goodman SL]]
-
[[Category: Joachimiak, A.]]
+
[[Category: Joachimiak A]]
-
[[Category: Stehle, T.]]
+
[[Category: Stehle T]]
-
[[Category: Xiong, J P.]]
+
[[Category: Xiong J-P]]
-
[[Category: Zhang, R.]]
+
[[Category: Zhang R]]
-
[[Category: A-domain]]
+
-
[[Category: Admida]]
+
-
[[Category: Beta-tail domain]]
+
-
[[Category: Cage motif]]
+
-
[[Category: Calf domain]]
+
-
[[Category: Egf domain]]
+
-
[[Category: Genu]]
+
-
[[Category: Hybrid domain]]
+
-
[[Category: Mida]]
+
-
[[Category: Propeller]]
+
-
[[Category: Psi domain]]
+
-
[[Category: Thigh domain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:02:22 2008''
+

Current revision

CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+

PDB ID 1m1x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m1x"
Personal tools