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1m49
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1m49.png|left|200px]] | ||
| - | + | ==Crystal Structure of Human Interleukin-2 Complexed with SP-1985== | |
| - | + | <StructureSection load='1m49' size='340' side='right'caption='[[1m49]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1m49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M49 FirstGlance]. <br> | |
| - | or | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMM:2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC+ACID+METHYL+ESTER'>CMM</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m49 OCA], [https://pdbe.org/1m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m49 RCSB], [https://www.ebi.ac.uk/pdbsum/1m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m49 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m49_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m49 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arkin | + | [[Category: Arkin MA]] |
| - | [[Category: Braisted | + | [[Category: Braisted AC]] |
| - | [[Category: DeLano | + | [[Category: DeLano WL]] |
| - | [[Category: Hyde | + | [[Category: Hyde J]] |
| - | [[Category: Luong | + | [[Category: Luong TN]] |
| - | [[Category: McDowell | + | [[Category: McDowell RS]] |
| - | [[Category: Oslob | + | [[Category: Oslob JD]] |
| - | [[Category: Randal | + | [[Category: Randal M]] |
| - | [[Category: Raphael | + | [[Category: Raphael DR]] |
| - | [[Category: Taylor | + | [[Category: Taylor L]] |
| - | [[Category: Wang | + | [[Category: Wang J]] |
| - | [[Category: Wells | + | [[Category: Wells JA]] |
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Current revision
Crystal Structure of Human Interleukin-2 Complexed with SP-1985
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Categories: Homo sapiens | Large Structures | Arkin MA | Braisted AC | DeLano WL | Hyde J | Luong TN | McDowell RS | Oslob JD | Randal M | Raphael DR | Taylor L | Wang J | Wells JA
