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1m4a

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{{STRUCTURE_1m4a| PDB=1m4a | SCENE= }}
 
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===Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid===
 
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{{ABSTRACT_PUBMED_12582206}}
 
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==Disease==
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==Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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<StructureSection load='1m4a' size='340' side='right'caption='[[1m4a]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1m4a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4A FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPE:(1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC+ACID'>MPE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4a OCA], [https://pdbe.org/1m4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4a RCSB], [https://www.ebi.ac.uk/pdbsum/1m4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4a ProSAT]</span></td></tr>
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[[1m4a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4A OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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== Function ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4a ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012582206</ref><ref group="xtra">PMID:012767230</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arkin, M A.]]
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[[Category: Large Structures]]
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[[Category: Braisted, A C.]]
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[[Category: Arkin MA]]
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[[Category: DeLano, W L.]]
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[[Category: Braisted AC]]
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[[Category: Hyde, J.]]
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[[Category: DeLano WL]]
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[[Category: Luong, T N.]]
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[[Category: Hyde J]]
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[[Category: McDowell, R S.]]
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[[Category: Luong TN]]
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[[Category: Oslob, J D.]]
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[[Category: McDowell RS]]
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[[Category: Randal, M.]]
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[[Category: Oslob JD]]
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[[Category: Raphael, D R.]]
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[[Category: Randal M]]
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[[Category: Taylor, L.]]
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[[Category: Raphael DR]]
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[[Category: Wang, J.]]
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[[Category: Taylor L]]
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[[Category: Wells, J A.]]
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[[Category: Wang J]]
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[[Category: Cytokine]]
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[[Category: Wells JA]]
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[[Category: Four-helix bundle]]
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[[Category: Small molecule complex]]
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Current revision

Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid

PDB ID 1m4a

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