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1m60

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[[Image:1m60.png|left|200px]]
 
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{{STRUCTURE_1m60| PDB=1m60 | SCENE= }}
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==Solution Structure of Zinc-substituted cytochrome c==
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<StructureSection load='1m60' size='340' side='right'caption='[[1m60]]' scene=''>
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===Solution Structure of Zinc-substituted cytochrome c===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M60 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12761660}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HES:ZINC+SUBSTITUTED+HEME+C'>HES</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m60 OCA], [https://pdbe.org/1m60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m60 RCSB], [https://www.ebi.ac.uk/pdbsum/1m60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m60 ProSAT]</span></td></tr>
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[[1m60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m60_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m60 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cytochrome c|Cytochrome c]]
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012761660</ref><references group="xtra"/>
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[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: Qian, C.]]
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[[Category: Large Structures]]
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[[Category: Tang, W.]]
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[[Category: Qian C]]
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[[Category: Tong, Y.]]
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[[Category: Tang W]]
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[[Category: Wang, J.]]
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[[Category: Tong Y]]
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[[Category: Yao, Y.]]
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[[Category: Wang J]]
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[[Category: Electron transport]]
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[[Category: Yao Y]]
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[[Category: Six-coordinated zinc cyt c]]
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Current revision

Solution Structure of Zinc-substituted cytochrome c

PDB ID 1m60

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OCA

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