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1mc0

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[[Image:1mc0.png|left|200px]]
 
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{{STRUCTURE_1mc0| PDB=1mc0 | SCENE= }}
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==Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains==
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<StructureSection load='1mc0' size='340' side='right'caption='[[1mc0]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MC0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mc0 OCA], [https://pdbe.org/1mc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mc0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mc0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE2A_MOUSE PDE2A_MOUSE] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/1mc0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mc0 ConSurf].
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<div style="clear:both"></div>
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===Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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{{ABSTRACT_PUBMED_12271124}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1mc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MC0 OCA].
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==Reference==
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<ref group="xtra">PMID:012271124</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Beavo, J.]]
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[[Category: Beavo J]]
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[[Category: Glavas, N.]]
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[[Category: Glavas N]]
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[[Category: Hol, W.]]
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[[Category: Hol W]]
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[[Category: Martinez, S.]]
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[[Category: Martinez S]]
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[[Category: Tang, X.]]
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[[Category: Tang X]]
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[[Category: Turley, S.]]
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[[Category: Turley S]]
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[[Category: Wu, A.]]
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[[Category: Wu A]]
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[[Category: 3s']]
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[[Category: 5'-cyclic nucleotide phosphodiesterase]]
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[[Category: 5'-guanosine monophosphate]]
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[[Category: Gaf domain]]
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[[Category: Hydrolase]]
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Current revision

Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

PDB ID 1mc0

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