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1mir

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(New page: 200px<br /> <applet load="1mir" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mir, resolution 2.8&Aring;" /> '''RAT PROCATHEPSIN B''...)
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[[Image:1mir.gif|left|200px]]<br />
 
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<applet load="1mir" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mir, resolution 2.8&Aring;" />
 
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'''RAT PROCATHEPSIN B'''<br />
 
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==Overview==
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==RAT PROCATHEPSIN B==
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BACKGROUND: Cysteine proteases of the papain superfamily are synthesized, as inactive precursors with a 60-110 residue N-terminal prosegment. The, propeptides are potent inhibitors of their parent proteases. Although the, proregion binding mode has been elucidated for all other protease classes, that of the cysteine proteases remained elusive. RESULTS: We report the, three-dimensional structure of rat procathepsin B, determined at 2.8 A, resolution. The 62-residue proregion does not form a globular structure on, its own, but folds along the surface of mature cathepsin B. The N-terminal, part of the proregion packs against a surface loop, with Trp24p (p, indicating the proregion) playing a pivotal role in these interactions., Inhibition occurs by blocking access to the active site: part of ... [[http://ispc.weizmann.ac.il/pmbin/getpm?8740363 (full description)]]
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<StructureSection load='1mir' size='340' side='right'caption='[[1mir]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mir]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MIR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mir OCA], [https://pdbe.org/1mir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mir RCSB], [https://www.ebi.ac.uk/pdbsum/1mir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mir ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_RAT CATB_RAT] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mi/1mir_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mir ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1MIR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MIR OCA]].
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion., Cygler M, Sivaraman J, Grochulski P, Coulombe R, Storer AC, Mort JS, Structure. 1996 Apr 15;4(4):405-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8740363 8740363]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Coulombe R]]
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[[Category: Coulombe, R.]]
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[[Category: Cygler M]]
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[[Category: Cygler, M.]]
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[[Category: Grochulski P]]
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[[Category: Grochulski, P.]]
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[[Category: Mort JS]]
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[[Category: Mort, J.S.]]
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[[Category: Sivaraman J]]
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[[Category: Sivaraman, J.]]
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[[Category: Storer AC]]
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[[Category: Storer, A.C.]]
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[[Category: cysteine protease]]
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[[Category: hydrolase]]
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[[Category: thiol protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:45:32 2007''
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Current revision

RAT PROCATHEPSIN B

PDB ID 1mir

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