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1ml7

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[[Image:1ml7.png|left|200px]]
 
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{{STRUCTURE_1ml7| PDB=1ml7 | SCENE= }}
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==Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole==
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<StructureSection load='1ml7' size='340' side='right'caption='[[1ml7]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ml7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEV:5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC+ACID+FERROUS+COMPLEX'>HEV</scene>, <scene name='pdbligand=PYZ:4-IODOPYRAZOLE'>PYZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml7 OCA], [https://pdbe.org/1ml7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml7 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole===
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==See Also==
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*[[Nitrophorin|Nitrophorin]]
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{{ABSTRACT_PUBMED_14673714}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1ml7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML7 OCA].
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==Reference==
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<ref group="xtra">PMID:014673714</ref><ref group="xtra">PMID:019140692</ref><references group="xtra"/>
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[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
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[[Category: Berry, R E.]]
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[[Category: Berry RE]]
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[[Category: Ding, X D.]]
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[[Category: Ding XD]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort WR]]
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[[Category: Walker, F A.]]
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[[Category: Walker FA]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel A]]
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[[Category: Beta barrel]]
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[[Category: Conformational change]]
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[[Category: Ferric heme]]
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[[Category: Iodopyrazole]]
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[[Category: Ligand binding protein]]
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[[Category: Lipocalin]]
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[[Category: No carrier]]
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Current revision

Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole

PDB ID 1ml7

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