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1mqm

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{{Seed}}
 
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[[Image:1mqm.png|left|200px]]
 
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<!--
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==BHA/LSTa==
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The line below this paragraph, containing "STRUCTURE_1mqm", creates the "Structure Box" on the page.
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<StructureSection load='1mqm' size='340' side='right'caption='[[1mqm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mqm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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{{STRUCTURE_1mqm| PDB=1mqm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqm OCA], [https://pdbe.org/1mqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqm RCSB], [https://www.ebi.ac.uk/pdbsum/1mqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_I63A3 HEMA_I63A3] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqm ConSurf].
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<div style="clear:both"></div>
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===BHA/LSTa===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12758169}}, adds the Publication Abstract to the page
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[[Category: Influenza A virus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12758169 is the PubMed ID number.
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[[Category: Large Structures]]
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-->
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[[Category: Ha y]]
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{{ABSTRACT_PUBMED_12758169}}
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[[Category: Skehel jj]]
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[[Category: Steven dj]]
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==About this Structure==
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[[Category: Wiley dc]]
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1MQM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQM OCA].
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==Reference==
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X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, Virology. 2003 May 10;309(2):209-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12758169 12758169]
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[[Category: Influenza a virus]]
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[[Category: Protein complex]]
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[[Category: Ha, y.]]
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[[Category: Skehel, j j.]]
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[[Category: Steven, d j.]]
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[[Category: Wiley, d c.]]
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[[Category: Influenza virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 01:41:33 2008''
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Current revision

BHA/LSTa

PDB ID 1mqm

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