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1mr6
From Proteopedia
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| - | [[Image:1mr6.png|left|200px]] | ||
| - | + | ==Solution Structure of gamma-Bungarotoxin:Implication for the role of the Residues Adjacent to RGD in Integrin Binding== | |
| - | + | <StructureSection load='1mr6' size='340' side='right'caption='[[1mr6]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1mr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr6 OCA], [https://pdbe.org/1mr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr6 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr6 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1mr6]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/3NO5I_BUNMU 3NO5I_BUNMU] Exhibits M2 muscarinic acetylcholine receptor (CHRM2)-blocking activity, but has a weak binding activity toward nicotinic AChR. Moreover, it inhibits collagen-induced platelet aggregation.<ref>PMID:12168693</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Bungarotoxin|Bungarotoxin]] | + | *[[Bungarotoxin 3D structures|Bungarotoxin 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Bungarus multicinctus]] | [[Category: Bungarus multicinctus]] | ||
| - | [[Category: Chang | + | [[Category: Large Structures]] |
| - | [[Category: Chen | + | [[Category: Chang L-S]] |
| - | [[Category: Chen | + | [[Category: Chen C-Y]] |
| - | [[Category: Chuang | + | [[Category: Chen Y-C]] |
| - | [[Category: Shiu | + | [[Category: Chuang W-J]] |
| - | + | [[Category: Shiu J-H]] | |
| - | + | ||
| - | + | ||
Current revision
Solution Structure of gamma-Bungarotoxin:Implication for the role of the Residues Adjacent to RGD in Integrin Binding
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