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1muj

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(New page: 200px<br /><applet load="1muj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1muj, resolution 2.15&Aring;" /> '''Crystal structure of...)
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[[Image:1muj.gif|left|200px]]<br /><applet load="1muj" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1muj, resolution 2.15&Aring;" />
 
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'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''<br />
 
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==Overview==
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==Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide==
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Association between the class II major histocompatibility complex (MHC), and the class II invariant chain-associated peptide (CLIP) occurs, naturally as an intermediate step in the MHC class II processing pathway., Here, we report the crystal structure of the murine class II MHC molecule, I-A(b) in complex with human CLIP at 2.15A resolution. The structure of, I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a, similar conformation to peptides bound by other I-A alleles, reinforcing, the notion that CLIP is presented as a conventional peptide antigen. When, compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide, displays a slightly different conformation and distinct interaction, pattern with residues in I-A(b). In addition, after examining the, published sequences of peptides presented by I-A(b), we discuss the, possibility of predicting peptide alignment in the I-A(b) binding groove, using a simple scoring matrix.
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<StructureSection load='1muj' size='340' side='right'caption='[[1muj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1muj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MUJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muj OCA], [https://pdbe.org/1muj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1muj RCSB], [https://www.ebi.ac.uk/pdbsum/1muj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1muj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/1muj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1muj ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1MUJ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MUJ OCA].
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC II 3D structures|MHC II 3D structures]]
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==Reference==
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__TOC__
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Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12589760 12589760]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I.A.]]
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[[Category: Zhu Y]]
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[[Category: Zhu, Y.]]
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[[Category: NAG]]
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[[Category: antigen]]
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[[Category: clip]]
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[[Category: complex]]
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[[Category: crystal structure]]
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[[Category: i-ab]]
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[[Category: peptide]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:42:36 2007''
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Current revision

Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide

PDB ID 1muj

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