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1mup

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[[Image:1mup.gif|left|200px]]
 
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{{Structure
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==PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY==
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|PDB= 1mup |SIZE=350|CAPTION= <scene name='initialview01'>1mup</scene>, resolution 2.4&Aring;
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<StructureSection load='1mup' size='340' side='right'caption='[[1mup]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TZL:2-(SEC-BUTYL)THIAZOLE'>TZL</scene>
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<table><tr><td colspan='2'>[[1mup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MUP FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TZL:2-(SEC-BUTYL)THIAZOLE'>TZL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mup OCA], [https://pdbe.org/1mup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mup RCSB], [https://www.ebi.ac.uk/pdbsum/1mup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mup ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mup OCA], [http://www.ebi.ac.uk/pdbsum/1mup PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mup RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MUP6_MOUSE MUP6_MOUSE] Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.
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== Evolutionary Conservation ==
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'''PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/1mup_consurf.spt"</scriptWhenChecked>
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The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1MUP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUP OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mup ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography., Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC, Nature. 1992 Nov 12;360(6400):186-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1279439 1279439]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Bocskei Z]]
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[[Category: Bocskei, Z.]]
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[[Category: Flower DR]]
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[[Category: Flower, D R.]]
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[[Category: Groom CR]]
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[[Category: Groom, C R.]]
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[[Category: North ACT]]
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[[Category: North, A C.T.]]
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[[Category: Phillips SEV]]
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[[Category: Phillips, S E.V.]]
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[[Category: pheromone-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:21 2008''
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Current revision

PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY

PDB ID 1mup

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