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1mx0

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[[Image:1mx0.png|left|200px]]
 
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{{STRUCTURE_1mx0| PDB=1mx0 | SCENE= }}
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==Structure of topoisomerase subunit==
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<StructureSection load='1mx0' size='340' side='right'caption='[[1mx0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Structure of topoisomerase subunit===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mx0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_shibatae Saccharolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MX0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12505993}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mx0 OCA], [https://pdbe.org/1mx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mx0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mx0 ProSAT]</span></td></tr>
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[[1mx0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_shibatae Sulfolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX0 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP6B_SACSH TOP6B_SACSH] Relaxes both positive and negative supercoils and exhibits a strong decatenase and unknotting activity; it cannot introduce DNA supercoils (PubMed:7961685). ATP is absolutely required for DNA cleavage; the nonhydrolyzable analog AMP-PNP generates nicked or linear products from a supercoiled dsDNA substrate. Generates staggered two-nucleotide long 5' overhangs. The enzyme is covalently attached transiently to the 5'-ends of the cleaved strands (PubMed:11485995).<ref>PMID:11485995</ref> <ref>PMID:7961685</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mx0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mx0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012505993</ref><references group="xtra"/>
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__TOC__
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[[Category: Sulfolobus shibatae]]
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</StructureSection>
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[[Category: Berger, J M.]]
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[[Category: Large Structures]]
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[[Category: Corbett, K D.]]
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[[Category: Saccharolobus shibatae]]
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[[Category: Ghkl atpase]]
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[[Category: Berger JM]]
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[[Category: Isomerase]]
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[[Category: Corbett KD]]
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[[Category: Topoisomerase]]
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Current revision

Structure of topoisomerase subunit

PDB ID 1mx0

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