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1mzj
From Proteopedia
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| - | [[Image:1mzj.png|left|200px]] | ||
| - | + | ==Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway== | |
| - | + | <StructureSection load='1mzj' size='340' side='right'caption='[[1mzj]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1mzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._R1128 Streptomyces sp. R1128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzj OCA], [https://pdbe.org/1mzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzj RCSB], [https://www.ebi.ac.uk/pdbsum/1mzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzj ProSAT]</span></td></tr> |
| - | [[1mzj]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FABH_STRLI FABH_STRLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate preference for butyryl-CoA and can tolerate branched substrates. Can also prime acyl-CoA. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Involved in the biosynthesis of R1128 polyketide.<ref>PMID:11732905</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Acyl carrier protein synthase|Acyl carrier protein synthase]] | + | *[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Streptomyces sp. | + | [[Category: Large Structures]] |
| - | + | [[Category: Streptomyces sp. R1128]] | |
| - | [[Category: Keatinge-Clay | + | [[Category: Keatinge-Clay A]] |
| - | [[Category: Khosla | + | [[Category: Khosla C]] |
| - | [[Category: Meadows | + | [[Category: Meadows ES]] |
| - | [[Category: Miercke | + | [[Category: Miercke LJW]] |
| - | [[Category: | + | [[Category: O'Connell J]] |
| - | [[Category: | + | [[Category: Pan H]] |
| - | [[Category: | + | [[Category: Stroud RM]] |
| - | [[Category: | + | [[Category: Tsai SC]] |
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Current revision
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
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