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1mzj

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{{Seed}}
 
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[[Image:1mzj.png|left|200px]]
 
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<!--
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==Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway==
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The line below this paragraph, containing "STRUCTURE_1mzj", creates the "Structure Box" on the page.
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<StructureSection load='1mzj' size='340' side='right'caption='[[1mzj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._R1128 Streptomyces sp. R1128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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{{STRUCTURE_1mzj| PDB=1mzj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzj OCA], [https://pdbe.org/1mzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzj RCSB], [https://www.ebi.ac.uk/pdbsum/1mzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABH_STRLI FABH_STRLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate preference for butyryl-CoA and can tolerate branched substrates. Can also prime acyl-CoA. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Involved in the biosynthesis of R1128 polyketide.<ref>PMID:11732905</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzj ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway===
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==See Also==
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12429097}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12429097 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12429097}}
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[[Category: Streptomyces sp. R1128]]
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[[Category: Keatinge-Clay A]]
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==About this Structure==
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[[Category: Khosla C]]
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1MZJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._r1128 Streptomyces sp. r1128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZJ OCA].
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[[Category: Meadows ES]]
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[[Category: Miercke LJW]]
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==Reference==
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[[Category: O'Connell J]]
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Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway., Pan H, Tsai S, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM, Structure. 2002 Nov;10(11):1559-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12429097 12429097]
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[[Category: Pan H]]
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[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
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[[Category: Stroud RM]]
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[[Category: Single protein]]
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[[Category: Tsai SC]]
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[[Category: Streptomyces sp. r1128]]
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[[Category: Connell, J O.]]
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[[Category: Keatinge-Clay, A.]]
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[[Category: Khosla, C.]]
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[[Category: Meadows, E S.]]
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[[Category: Miercke, L J.W.]]
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[[Category: Pan, H.]]
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[[Category: Stroud, R M.]]
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[[Category: Tsai, S C.]]
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[[Category: Aromatic polyketide]]
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[[Category: Beta-ketosynthase]]
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[[Category: Biosynthetic engineering]]
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[[Category: Catalytic triad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:12:38 2008''
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Current revision

Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway

PDB ID 1mzj

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