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1n1c

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(New page: 200px<br /><applet load="1n1c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1c, resolution 2.40&Aring;" /> '''Crystal Structure Of...)
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[[Image:1n1c.gif|left|200px]]<br /><applet load="1n1c" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n1c, resolution 2.40&Aring;" />
 
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'''Crystal Structure Of The Dimeric TorD Chaperone From Shewanella Massilia'''<br />
 
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==Overview==
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==Crystal Structure Of The Dimeric TorD Chaperone From Shewanella Massilia==
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TorD is the cytoplasmic chaperone involved in the maturation of the, molybdoenzyme TorA prior to the translocation of the folded protein into, the periplasm. The X-ray structure at 2.4 A resolution of the TorD dimer, reveals extreme domain swapping between the two subunits. The all-helical, architecture of the globular domains within the intertwined molecular, dimer shows no similarity with known protein structures. According to, sequence similarities, this new fold probably represents the architecture, of the chaperones associated with the bacterial DMSO/TMAO reductases and, also that of proteins of yet unknown functions. The occurrence of multiple, oligomeric forms and the chaperone activity of both monomeric and dimeric, TorD raise questions about the possible biological role of domain swapping, in this protein.
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<StructureSection load='1n1c' size='340' side='right'caption='[[1n1c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1n1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_massilia Shewanella massilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1C FirstGlance]. <br>
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1N1C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Shewanella_massilia Shewanella massilia] with DTT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N1C OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1c OCA], [https://pdbe.org/1n1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1c RCSB], [https://www.ebi.ac.uk/pdbsum/1n1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1c ProSAT]</span></td></tr>
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A novel protein fold and extreme domain swapping in the dimeric TorD chaperone from Shewanella massilia., Tranier S, Iobbi-Nivol C, Birck C, Ilbert M, Mortier-Barriere I, Mejean V, Samama JP, Structure. 2003 Feb;11(2):165-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12575936 12575936]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TORD_SHEMA TORD_SHEMA] Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1c ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Shewanella massilia]]
[[Category: Shewanella massilia]]
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[[Category: Single protein]]
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[[Category: Birck C]]
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[[Category: Birck, C.]]
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[[Category: Iobbi-Nivol C]]
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[[Category: Iobbi-Nivol, C.]]
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[[Category: Mejean V]]
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[[Category: Mejean, V.]]
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[[Category: Mortier-Barriere I]]
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[[Category: Mortier-Barriere, I.]]
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[[Category: Samama J-P]]
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[[Category: Samama, J.P.]]
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[[Category: Tranier S]]
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[[Category: Tranier, S.]]
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[[Category: DTT]]
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[[Category: 3d-domain swapping]]
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[[Category: chaperone]]
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[[Category: tord]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:52:04 2007''
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Current revision

Crystal Structure Of The Dimeric TorD Chaperone From Shewanella Massilia

PDB ID 1n1c

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