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1n1f

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[[Image:1n1f.jpg|left|200px]]<br /><applet load="1n1f" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n1f, resolution 1.95&Aring;" />
 
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'''Crystal Structure of Human Interleukin-19'''<br />
 
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==Overview==
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==Crystal Structure of Human Interleukin-19==
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Interleukin-19 (IL-19) is a novel cytokine that was initially identified, during a sequence data base search aimed at finding potential IL-10, homologs. IL-19 shares a receptor complex with IL-20, indicating that the, biological activities of these two cytokines overlap and that both may, play an important role in regulating development and proper functioning of, the skin. We determined the crystal structure of human recombinant IL-19, and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made, of seven amphipathic helices, A-G, creating a unique helical bundle. On, the basis of the observed structure, we propose that IL-19, IL-20, and, other putative members of the proposed IL-10 family together form a, distinct subfamily of helical cytokines.
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<StructureSection load='1n1f' size='340' side='right'caption='[[1n1f]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1f OCA], [https://pdbe.org/1n1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1f RCSB], [https://www.ebi.ac.uk/pdbsum/1n1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL19_HUMAN IL19_HUMAN] May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n1f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1f ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1N1F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1F OCA].
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12403790 12403790]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chang, C.]]
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[[Category: Chang C]]
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[[Category: Fong, S.]]
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[[Category: Fong S]]
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[[Category: Kotenko, S.]]
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[[Category: Kotenko S]]
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[[Category: Kozlov, S.]]
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[[Category: Kozlov S]]
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[[Category: Magracheva, E.]]
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[[Category: Magracheva E]]
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[[Category: Tobin, G.]]
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[[Category: Tobin G]]
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[[Category: Wlodawer, A.]]
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[[Category: Wlodawer A]]
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[[Category: Zdanov, A.]]
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[[Category: Zdanov A]]
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[[Category: NAG]]
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[[Category: cytokine]]
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[[Category: four helix bundle]]
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[[Category: interleukin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:26:30 2008''
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Current revision

Crystal Structure of Human Interleukin-19

PDB ID 1n1f

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