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1n28

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{{Seed}}
 
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[[Image:1n28.png|left|200px]]
 
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==Crystal structure of the H48Q mutant of human group IIA phospholipase A2==
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The line below this paragraph, containing "STRUCTURE_1n28", creates the "Structure Box" on the page.
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<StructureSection load='1n28' size='340' side='right'caption='[[1n28]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N28 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1n28| PDB=1n28 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n28 OCA], [https://pdbe.org/1n28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n28 RCSB], [https://www.ebi.ac.uk/pdbsum/1n28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n28 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/1n28_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n28 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the H48Q mutant of human group IIA phospholipase A2===
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12501175}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12501175 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12501175}}
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==About this Structure==
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1N28 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N28 OCA].
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==Reference==
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The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism., Edwards SH, Thompson D, Baker SF, Wood SP, Wilton DC, Biochemistry. 2002 Dec 31;41(52):15468-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12501175 12501175]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, S F.]]
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[[Category: Baker SF]]
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[[Category: Edwards, S H.]]
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[[Category: Edwards SH]]
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[[Category: Thompson, D.]]
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[[Category: Thompson D]]
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[[Category: Wilton, D C.]]
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[[Category: Wilton DC]]
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[[Category: Wood, S P.]]
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[[Category: Wood SP]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:59:44 2008''
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Current revision

Crystal structure of the H48Q mutant of human group IIA phospholipase A2

PDB ID 1n28

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