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1n4a

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{{Seed}}
 
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[[Image:1n4a.png|left|200px]]
 
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<!--
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==The Ligand Bound Structure of E.coli BtuF, the Periplasmic Binding Protein for Vitamin B12==
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The line below this paragraph, containing "STRUCTURE_1n4a", creates the "Structure Box" on the page.
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<StructureSection load='1n4a' size='340' side='right'caption='[[1n4a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1n4a| PDB=1n4a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4a OCA], [https://pdbe.org/1n4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4a RCSB], [https://www.ebi.ac.uk/pdbsum/1n4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4a ProSAT], [https://www.topsan.org/Proteins/NESGC/1n4a TOPSAN]</span></td></tr>
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</table>
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===The Ligand Bound Structure of E.coli BtuF, the Periplasmic Binding Protein for Vitamin B12===
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== Function ==
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[https://www.uniprot.org/uniprot/BTUF_ECOLI BTUF_ECOLI] Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.<ref>PMID:11790740</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12468528}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12468528 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12468528}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1N4A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding., Karpowich NK, Huang HH, Smith PC, Hunt JF, J Biol Chem. 2003 Mar 7;278(10):8429-34. Epub 2002 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12468528 12468528]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hunt, J F.]]
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[[Category: Large Structures]]
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[[Category: Karpowich, N K]]
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[[Category: Hunt JF]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Karpowich NK]]
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[[Category: Smith, P C.]]
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[[Category: Smith PC]]
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[[Category: Abc transporter]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Periplasmic binding protein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Transmembrane transport]]
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[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:58:44 2008''
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Current revision

The Ligand Bound Structure of E.coli BtuF, the Periplasmic Binding Protein for Vitamin B12

PDB ID 1n4a

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