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1n76
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1n76" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n76, resolution 3.400Å" /> '''CRYSTAL STRUCTURE ...) |
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| - | [[Image:1n76.gif|left|200px]]<br /> | ||
| - | <applet load="1n76" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1n76, resolution 3.400Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION'''<br /> | ||
| - | == | + | ==CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION== |
| - | + | <StructureSection load='1n76' size='340' side='right'caption='[[1n76]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1n76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N76 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n76 OCA], [https://pdbe.org/1n76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n76 RCSB], [https://www.ebi.ac.uk/pdbsum/1n76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n76 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/1n76_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n76 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Lactoferrin|Lactoferrin]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Betzel | + | [[Category: Betzel C]] |
| - | [[Category: Bhushan | + | [[Category: Bhushan A]] |
| - | [[Category: Kaur | + | [[Category: Kaur P]] |
| - | [[Category: Kumar | + | [[Category: Kumar J]] |
| - | [[Category: Munchau | + | [[Category: Munchau S]] |
| - | [[Category: Paramsivam | + | [[Category: Paramsivam M]] |
| - | [[Category: Sarvanan | + | [[Category: Sarvanan K]] |
| - | [[Category: Sharma | + | [[Category: Sharma S]] |
| - | [[Category: Singh | + | [[Category: Singh SB]] |
| - | [[Category: Singh | + | [[Category: Singh TP]] |
| - | [[Category: Srinivasan | + | [[Category: Srinivasan A]] |
| - | [[Category: Weber | + | [[Category: Weber W]] |
| - | [[Category: Yadav | + | [[Category: Yadav S]] |
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Current revision
CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION
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Categories: Homo sapiens | Large Structures | Betzel C | Bhushan A | Kaur P | Kumar J | Munchau S | Paramsivam M | Sarvanan K | Sharma S | Singh SB | Singh TP | Srinivasan A | Weber W | Yadav S
