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1n76

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{{Seed}}
 
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[[Image:1n76.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_1n76", creates the "Structure Box" on the page.
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<StructureSection load='1n76' size='340' side='right'caption='[[1n76]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N76 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1n76| PDB=1n76 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n76 OCA], [https://pdbe.org/1n76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n76 RCSB], [https://www.ebi.ac.uk/pdbsum/1n76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n76 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/1n76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n76 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION===
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==See Also==
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*[[Lactoferrin|Lactoferrin]]
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== References ==
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==About this Structure==
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<references/>
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1N76 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N76 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Betzel, Ch.]]
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[[Category: Large Structures]]
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[[Category: Bhushan, A.]]
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[[Category: Betzel C]]
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[[Category: Kaur, P.]]
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[[Category: Bhushan A]]
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[[Category: Kumar, J.]]
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[[Category: Kaur P]]
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[[Category: Munchau, S.]]
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[[Category: Kumar J]]
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[[Category: Paramsivam, M.]]
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[[Category: Munchau S]]
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[[Category: Sarvanan, K.]]
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[[Category: Paramsivam M]]
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[[Category: Sharma, S.]]
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[[Category: Sarvanan K]]
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[[Category: Singh, S B.]]
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[[Category: Sharma S]]
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[[Category: Singh, T P.]]
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[[Category: Singh SB]]
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[[Category: Srinivasan, A.]]
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[[Category: Singh TP]]
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[[Category: Weber, W.]]
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[[Category: Srinivasan A]]
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[[Category: Yadav, S.]]
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[[Category: Weber W]]
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[[Category: Crystal structure]]
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[[Category: Yadav S]]
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[[Category: Human seminal lactoferrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:02:40 2009''
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Current revision

CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION

PDB ID 1n76

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