1nek

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[[Image:1nek.png|left|200px]]
 
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{{STRUCTURE_1nek| PDB=1nek | SCENE= }}
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==Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound==
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<StructureSection load='1nek' size='340' side='right'caption='[[1nek]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nek]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEK FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12560550}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDN:CARDIOLIPIN'>CDN</scene>, <scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=UQ2:UBIQUINONE-2'>UQ2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nek OCA], [https://pdbe.org/1nek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nek RCSB], [https://www.ebi.ac.uk/pdbsum/1nek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nek ProSAT]</span></td></tr>
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[[1nek]] is a 4 chain structure of [[Succinate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEK OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDHA_ECOLI SDHA_ECOLI] Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.<ref>PMID:24374335</ref> <ref>PMID:12560550</ref> <ref>PMID:16407191</ref> <ref>PMID:19710024</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nek_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nek ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Succinate Dehydrogenase|Succinate Dehydrogenase]]
*[[Succinate Dehydrogenase|Succinate Dehydrogenase]]
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*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:012560550</ref><ref group="xtra">PMID:015109257</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Citric Acid Cycle]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Byrne, B.]]
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[[Category: Large Structures]]
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[[Category: Cecchini, G.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Horsefield, R.]]
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[[Category: Byrne B]]
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[[Category: Iwata, S.]]
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[[Category: Cecchini G]]
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[[Category: Leger, C.]]
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[[Category: Horsefield R]]
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[[Category: Luna-Chavez, C.]]
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[[Category: Iwata S]]
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[[Category: Miyoshi, H.]]
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[[Category: Leger C]]
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[[Category: Tornroth, S.]]
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[[Category: Luna-Chavez C]]
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[[Category: Yankovskaya, V.]]
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[[Category: Miyoshi H]]
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[[Category: Membrane protein]]
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[[Category: Tornroth S]]
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[[Category: Oxidoreductase-electron transport complex]]
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[[Category: Yankovskaya V]]
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[[Category: Oxygen respiratory chain]]
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Current revision

Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound

PDB ID 1nek

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