This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nek

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 10 April 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nek.png|left|200px]]
 
-
{{STRUCTURE_1nek| PDB=1nek | SCENE= }}
+
==Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound==
-
 
+
<StructureSection load='1nek' size='340' side='right'caption='[[1nek]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1nek]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEK FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12560550}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDN:CARDIOLIPIN'>CDN</scene>, <scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=UQ2:UBIQUINONE-2'>UQ2</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nek OCA], [https://pdbe.org/1nek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nek RCSB], [https://www.ebi.ac.uk/pdbsum/1nek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nek ProSAT]</span></td></tr>
-
[[1nek]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEK OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SDHA_ECOLI SDHA_ECOLI] Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.<ref>PMID:24374335</ref> <ref>PMID:12560550</ref> <ref>PMID:16407191</ref> <ref>PMID:19710024</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nek_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nek ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
*[[Succinate Dehydrogenase|Succinate Dehydrogenase]]
*[[Succinate Dehydrogenase|Succinate Dehydrogenase]]
-
 
+
*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:012560550</ref><ref group="xtra">PMID:015109257</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Citric Acid Cycle]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Byrne, B.]]
+
[[Category: Large Structures]]
-
[[Category: Cecchini, G.]]
+
[[Category: RCSB PDB Molecule of the Month]]
-
[[Category: Horsefield, R.]]
+
[[Category: Byrne B]]
-
[[Category: Iwata, S.]]
+
[[Category: Cecchini G]]
-
[[Category: Leger, C.]]
+
[[Category: Horsefield R]]
-
[[Category: Luna-Chavez, C.]]
+
[[Category: Iwata S]]
-
[[Category: Miyoshi, H.]]
+
[[Category: Leger C]]
-
[[Category: Tornroth, S.]]
+
[[Category: Luna-Chavez C]]
-
[[Category: Yankovskaya, V.]]
+
[[Category: Miyoshi H]]
-
[[Category: Membrane protein]]
+
[[Category: Tornroth S]]
-
[[Category: Oxidoreductase-electron transport complex]]
+
[[Category: Yankovskaya V]]
-
[[Category: Oxygen respiratory chain]]
+

Current revision

Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound

PDB ID 1nek

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nek"
Personal tools