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1nkl

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(New page: 200px<br /><applet load="1nkl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nkl" /> '''NK-LYSIN FROM PIG, NMR, 20 STRUCTURES'''<br ...)
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[[Image:1nkl.gif|left|200px]]<br /><applet load="1nkl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nkl" />
 
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'''NK-LYSIN FROM PIG, NMR, 20 STRUCTURES'''<br />
 
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==Overview==
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==NK-LYSIN FROM PIG, NMR, 20 STRUCTURES==
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NK-lysin is the first representative of a family of sequence related, proteins--saposins, surfactant-associated protein B, pore forming amoeba, proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and, plant aspartic proteinases--for which a structure has been determined.
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<StructureSection load='1nkl' size='340' side='right'caption='[[1nkl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkl OCA], [https://pdbe.org/1nkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkl RCSB], [https://www.ebi.ac.uk/pdbsum/1nkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKL_PIG NKL_PIG] May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkl ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NKL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA].
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*[[Lysin 3D structures|Lysin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Saposin fold revealed by the NMR structure of NK-lysin., Liepinsh E, Andersson M, Ruysschaert JM, Otting G, Nat Struct Biol. 1997 Oct;4(10):793-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9334742 9334742]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Liepinsh, E.]]
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[[Category: Liepinsh E]]
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[[Category: Otting, G.]]
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[[Category: Otting G]]
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[[Category: antibacterial peptide]]
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[[Category: saposin fold]]
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[[Category: tumourolytic peptide]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:20:15 2007''
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NK-LYSIN FROM PIG, NMR, 20 STRUCTURES

PDB ID 1nkl

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