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1nkr

From Proteopedia

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[[Image:1nkr.gif|left|200px]]<br /><applet load="1nkr" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nkr, resolution 1.7&Aring;" />
 
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'''INHIBITORY RECEPTOR (P58-CL42) FOR HUMAN NATURAL KILLER CELLS'''<br />
 
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==Overview==
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==INHIBITORY RECEPTOR (P58-CL42) FOR HUMAN NATURAL KILLER CELLS==
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Abnormal cells deficient in class I major histocompatibility complex (MHC) expression are lysed by a class of lymphocytes called natural killer (NK) cells. This lysis provides a defence against pathogens and tumour cells that downregulate MHC expression to avoid an MHC-restricted, T-cell immune response. Normal cells escape lysis because their MHC molecules are recognized by NK-cell inhibitory receptors, which inhibit lysis. Several such inhibitory receptor families have been described in humans and mice. In the human killer-cell inhibitory receptor family, individual p58 members are specific for a subset of class I human leukocyte antigen (HLA)-C molecules. The human p58 natural killer-cell inhibitory receptor clone 42 recognizes HLA-Cw4, -Cw2 and -Cw6, but not HLA-Cw3, -Cw2, -Cw7 or -Cw8, which are recognized by p58 killer-cell inhibitor receptor clone 43. We have determined the X-ray structure of the p58 NK-cell inhibitory receptor clone 42 at 1.7-A resolution. The structure has tandem immunoglobulin-like domains positioned at an acute, 60-degree angle. Loops on the outside of the elbow between the domains form a binding site projected away from the NK-cell surface. The topology of the domains and their arrangement relative to each other reveal a relationship to the haematopoietic receptor family, with implications for the signalling mechanism in NK cells.
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<StructureSection load='1nkr' size='340' side='right'caption='[[1nkr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1nkr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKR FirstGlance]. <br>
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1NKR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkr OCA], [https://pdbe.org/1nkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkr RCSB], [https://www.ebi.ac.uk/pdbsum/1nkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkr ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors., Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC, Nature. 1997 Sep 4;389(6646):96-100. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9288975 9288975]
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== Function ==
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[https://www.uniprot.org/uniprot/KI2L1_HUMAN KI2L1_HUMAN] Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.<ref>PMID:18604210</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkr ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fan, Q R.]]
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[[Category: Fan QR]]
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[[Category: Long, E O.]]
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[[Category: Long EO]]
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[[Category: Mosyak, L.]]
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[[Category: Mosyak L]]
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[[Category: Wagtmann, N.]]
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[[Category: Wagtmann N]]
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[[Category: Wiley, D C.]]
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[[Category: Wiley DC]]
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[[Category: Winter, C C.]]
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[[Category: Winter CC]]
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[[Category: immunoglobulin fold]]
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[[Category: immunological receptors]]
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[[Category: inhibitory receptor]]
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[[Category: natural killer cells]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:07:07 2008''
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Current revision

INHIBITORY RECEPTOR (P58-CL42) FOR HUMAN NATURAL KILLER CELLS

PDB ID 1nkr

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