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1npl

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[[Image:1npl.png|left|200px]]
 
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{{STRUCTURE_1npl| PDB=1npl | SCENE= }}
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==MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM DAFFODIL (NARCISSUS PSEUDONARCISSUS) BULBS IN COMPLEX WITH MANNOSE-ALPHA1,3-MANNOSE==
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<StructureSection load='1npl' size='340' side='right'caption='[[1npl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1npl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Narcissus_pseudonarcissus Narcissus pseudonarcissus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRD_900112:3alpha-alpha-mannobiose'>PRD_900112</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npl OCA], [https://pdbe.org/1npl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npl RCSB], [https://www.ebi.ac.uk/pdbsum/1npl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEC_NARPS LEC_NARPS] D-mannose-binding lectin which binds alpha-D-linked mannose (PubMed:10388566, PubMed:1874921, PubMed:14505313, PubMed:2350177, PubMed:1645507). Displays a high affinity for alpha-(1-6)-mannose oligomers (PubMed:2350177, PubMed:1645507). Able to interact with both terminal and internal alpha-D-mannosyl residues (PubMed:2350177). Displays antiviral activity and therefore may contribute to defense against infections (PubMed:1645507, PubMed:7481093).<ref>PMID:10388566</ref> <ref>PMID:14505313</ref> <ref>PMID:1645507</ref> <ref>PMID:1874921</ref> <ref>PMID:2350177</ref> <ref>PMID:7481093</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npl ConSurf].
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<div style="clear:both"></div>
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===MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM DAFFODIL (NARCISSUS PSEUDONARCISSUS) BULBS IN COMPLEX WITH MANNOSE-ALPHA1,3-MANNOSE===
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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{{ABSTRACT_PUBMED_10388566}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1npl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Narcissus_pseudonarcissus Narcissus pseudonarcissus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPL OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:010388566</ref><references group="xtra"/>
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[[Category: Narcissus pseudonarcissus]]
[[Category: Narcissus pseudonarcissus]]
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[[Category: Grossmann, J G.]]
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[[Category: Grossmann JG]]
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[[Category: Reynolds, C D.]]
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[[Category: Reynolds CD]]
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[[Category: Rizkallah, P J.]]
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[[Category: Rizkallah PJ]]
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[[Category: Sauerborn, M K.]]
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[[Category: Sauerborn MK]]
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[[Category: Wright, L M.]]
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[[Category: Wright LM]]
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[[Category: 3-mannose]]
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[[Category: Agglutinin]]
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[[Category: Daffodil]]
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[[Category: Lectin]]
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[[Category: Mannobiose]]
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[[Category: Mannose-alpha1]]
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[[Category: Sugar binding protein]]
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Current revision

MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM DAFFODIL (NARCISSUS PSEUDONARCISSUS) BULBS IN COMPLEX WITH MANNOSE-ALPHA1,3-MANNOSE

PDB ID 1npl

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