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1nrb

From Proteopedia

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[[Image:1nrb.png|left|200px]]
 
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{{STRUCTURE_1nrb| PDB=1nrb | SCENE= }}
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==SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING==
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<StructureSection load='1nrb' size='340' side='right'caption='[[1nrb]]' scene=''>
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===SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NRB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7739052}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nrb OCA], [https://pdbe.org/1nrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nrb RCSB], [https://www.ebi.ac.uk/pdbsum/1nrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nrb ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1nrb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRB OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SCXV_CENSC SCXV_CENSC] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:007739052</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nrb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nrb ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Centruroides sculpturatus]]
[[Category: Centruroides sculpturatus]]
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[[Category: Jablonsky, M J.]]
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[[Category: Large Structures]]
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[[Category: Krishna, N R.]]
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[[Category: Jablonsky MJ]]
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[[Category: Neurotoxin]]
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[[Category: Krishna NR]]

Current revision

SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING

PDB ID 1nrb

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