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1nwt

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{{STRUCTURE_1nwt| PDB=1nwt | SCENE= }}
 
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===Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose===
 
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{{ABSTRACT_PUBMED_12851408}}
 
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==Disease==
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==Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose==
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[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[http://omim.org/entry/611960 611960]]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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<StructureSection load='1nwt' size='340' side='right'caption='[[1nwt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1nwt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWT FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwt OCA], [https://pdbe.org/1nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwt RCSB], [https://www.ebi.ac.uk/pdbsum/1nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwt ProSAT]</span></td></tr>
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[[1nwt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWT OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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== Function ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwt ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Chitinase-3-like protein 1|Chitinase-3-like protein 1]]
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*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012851408</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bos, E.]]
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[[Category: Large Structures]]
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[[Category: Dijkstra, B W.]]
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[[Category: Bos E]]
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[[Category: Fusetti, F.]]
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[[Category: Dijkstra BW]]
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[[Category: Kalk, K H.]]
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[[Category: Fusetti F]]
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[[Category: Pijning, T.]]
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[[Category: Kalk KH]]
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[[Category: Chitin]]
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[[Category: Pijning T]]
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[[Category: Chitinase-like protein]]
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[[Category: N-acetylglucosamine]]
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[[Category: Rheumatoid arthritis]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose

PDB ID 1nwt

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