This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nwt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:53, 10 April 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1nwt.png|left|200px]]
 
-
<!--
+
==Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose==
-
The line below this paragraph, containing "STRUCTURE_1nwt", creates the "Structure Box" on the page.
+
<StructureSection load='1nwt' size='340' side='right'caption='[[1nwt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1nwt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWT FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-
{{STRUCTURE_1nwt| PDB=1nwt | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwt OCA], [https://pdbe.org/1nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwt RCSB], [https://www.ebi.ac.uk/pdbsum/1nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwt ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwt_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwt ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose===
+
==See Also==
-
 
+
*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12851408}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 12851408 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_12851408}}
+
-
 
+
-
==About this Structure==
+
-
1NWT is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWT OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:12851408</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bos, E.]]
+
[[Category: Large Structures]]
-
[[Category: Dijkstra, B W.]]
+
[[Category: Bos E]]
-
[[Category: Fusetti, F.]]
+
[[Category: Dijkstra BW]]
-
[[Category: Kalk, K H.]]
+
[[Category: Fusetti F]]
-
[[Category: Pijning, T.]]
+
[[Category: Kalk KH]]
-
[[Category: Chitin]]
+
[[Category: Pijning T]]
-
[[Category: Chitinase-like protein]]
+
-
[[Category: N-acetylglucosamine]]
+
-
[[Category: Rheumatoid arthritis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:05:33 2009''
+

Current revision

Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose

PDB ID 1nwt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nwt"
Personal tools