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1nwv

From Proteopedia

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{{Seed}}
 
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[[Image:1nwv.png|left|200px]]
 
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<!--
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==SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR==
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The line below this paragraph, containing "STRUCTURE_1nwv", creates the "Structure Box" on the page.
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<StructureSection load='1nwv' size='340' side='right'caption='[[1nwv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwv OCA], [https://pdbe.org/1nwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwv RCSB], [https://www.ebi.ac.uk/pdbsum/1nwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwv ProSAT]</span></td></tr>
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{{STRUCTURE_1nwv| PDB=1nwv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwv ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR===
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==See Also==
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*[[CD55|CD55]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12672958}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12672958 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_12672958}}
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==About this Structure==
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1NWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWV OCA].
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==Reference==
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Solution structure of a functionally active fragment of decay-accelerating factor., Uhrinova S, Lin F, Ball G, Bromek K, Uhrin D, Medof ME, Barlow PN, Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4718-23. Epub 2003 Apr 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12672958 12672958]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ball, G.]]
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[[Category: Ball G]]
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[[Category: Barlow, P N.]]
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[[Category: Barlow PN]]
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[[Category: Bromek, K.]]
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[[Category: Bromek K]]
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[[Category: Lin, F.]]
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[[Category: Lin F]]
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[[Category: Medof, M E.]]
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[[Category: Medof ME]]
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[[Category: Uhrin, D.]]
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[[Category: Uhrin D]]
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[[Category: Uhrinova, S.]]
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[[Category: Uhrinova S]]
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[[Category: Ccp]]
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[[Category: Cd55]]
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[[Category: Complement]]
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[[Category: Daf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:47:27 2008''
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Current revision

SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR

PDB ID 1nwv

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