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1ny7

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(New page: 200px<br /><applet load="1ny7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ny7, resolution 3.00&Aring;" /> '''COWPEA MOSAIC VIRUS ...)
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[[Image:1ny7.gif|left|200px]]<br /><applet load="1ny7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ny7, resolution 3.00&Aring;" />
 
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'''COWPEA MOSAIC VIRUS (CPMV)'''<br />
 
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==Overview==
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==COWPEA MOSAIC VIRUS (CPMV)==
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Comoviruses are a group of plant viruses in the picornavirus superfamily., The type member of comoviruses, cowpea mosaic virus (CPMV), was, crystallized in the cubic space group I23, a = 317 A and the hexagonal, space group P6(1)22, a = 451 A, c = 1038 A. Structures of three closely, similar nucleoprotein particles were determined in the cubic form. The, roughly 300-A capsid was similar to the picornavirus capsid displaying a, pseudo T = 3 (P = 3) surface lattice. The three beta-sandwich domains, adopt two orientations, one with the long axis radial and the other two, with the long axes tangential in reference to the capsid sphere. T = 3, viruses display one or the other of these two orientations. The CPMV, capsid was permeable to cesium ions, leading to a disturbance of the, beta-annulus inside a channel-like structure, suggesting an ion channel., The hexagonal crystal form diffracted X rays to 3 A resolution, despite, the large unit cell. The large ( approximately 200 A) solvent channels in, the lattice allow exchange of CPMV cognate Fab fragments. As an initial, step in the structure determination of the CPMV/Fab complex, the P6(1)22, crystal structure was solved by molecular replacement with the CPMV model, determined in the cubic cell.
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<StructureSection load='1ny7' size='340' side='right'caption='[[1ny7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ny7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NY7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ny7 OCA], [https://pdbe.org/1ny7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ny7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ny7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ny7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POL2_CPMVS POL2_CPMVS] Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids. Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref> The cleavable C-terminus of small coat protein seems to be involved in the packaging of the virion RNAs. Also seems to act as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/1ny7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ny7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NY7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NY7 OCA].
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*[[Cowpea Chlorotic Mottle Virus|Cowpea Chlorotic Mottle Virus]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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==Reference==
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== References ==
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The refined crystal structure of cowpea mosaic virus at 2.8 A resolution., Lin T, Chen Z, Usha R, Stauffacher CV, Dai JB, Schmidt T, Johnson JE, Virology. 1999 Dec 5;265(1):20-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10603314 10603314]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cowpea mosaic virus]]
[[Category: Cowpea mosaic virus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Chen, Z.]]
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[[Category: Chen Z]]
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[[Category: Dai, J.B.]]
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[[Category: Dai J-B]]
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[[Category: Johnson, J.E.]]
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[[Category: Johnson JE]]
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[[Category: Lin, T.]]
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[[Category: Lin T]]
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[[Category: Schmidt, T.]]
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[[Category: Schmidt T]]
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[[Category: Stauffacher, C.V.]]
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[[Category: Stauffacher CV]]
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[[Category: Usha, R.]]
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[[Category: Usha R]]
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[[Category: comovirus]]
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[[Category: cowpea mosaic virus (cpmv)]]
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[[Category: icosahedral virus]]
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[[Category: viral coat protein]]
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[[Category: virus]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:39:10 2007''
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Current revision

COWPEA MOSAIC VIRUS (CPMV)

PDB ID 1ny7

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