This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1o9a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1o9a" [edit=sysop:move=sysop])
Current revision (08:56, 10 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1o9a.png|left|200px]]
 
-
<!--
+
==Solution structure of the complex of 1F12F1 from fibronectin with B3 from FnBB from S. dysgalactiae==
-
The line below this paragraph, containing "STRUCTURE_1o9a", creates the "Structure Box" on the page.
+
<StructureSection load='1o9a' size='340' side='right'caption='[[1o9a]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1o9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae Streptococcus dysgalactiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O9A FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9a OCA], [https://pdbe.org/1o9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o9a RCSB], [https://www.ebi.ac.uk/pdbsum/1o9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o9a ProSAT]</span></td></tr>
-
{{STRUCTURE_1o9a| PDB=1o9a | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===SOLUTION STRUCTURE OF THE COMPLEX OF 1F12F1 FROM FIBRONECTIN WITH B3 FROM FNBB FROM S. DYSGALACTIAE===
+
[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_12736686}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 12736686 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_12736686}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/1o9a_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[1o9a]] is a 2 chain structure of [[Fibronectin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9A OCA].
+
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o9a ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Fibronectin]]
+
*[[Fibronectin 3D structures|Fibronectin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:12736686</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Briggs, J A.G.]]
+
[[Category: Large Structures]]
-
[[Category: Campbell, I D.]]
+
[[Category: Streptococcus dysgalactiae]]
-
[[Category: Gough, T S.]]
+
[[Category: Briggs JAG]]
-
[[Category: Gurusiddappa, S.]]
+
[[Category: Campbell ID]]
-
[[Category: Hook, M.]]
+
[[Category: Gurusiddappa S]]
-
[[Category: Kim, J H.]]
+
[[Category: Hook M]]
-
[[Category: Pickford, A R.]]
+
[[Category: Pickford AR]]
-
[[Category: Pilka, E S.]]
+
[[Category: Pilka ES]]
-
[[Category: Potts, J R.]]
+
[[Category: Potts JR]]
-
[[Category: Schwarz-Linek, U.]]
+
[[Category: Schwarz-Linek U]]
-
[[Category: Werner, J M.]]
+
[[Category: Werner JM]]
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell adhesion/complex]]
+
-
[[Category: Fibronectin]]
+
-
[[Category: Host-pathogen protein complex]]
+

Current revision

Solution structure of the complex of 1F12F1 from fibronectin with B3 from FnBB from S. dysgalactiae

PDB ID 1o9a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o9a"
Personal tools