1oa6

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(New page: 200px<br /><applet load="1oa6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oa6" /> '''THE SOLUTION STRUCTURE OF BOVINE PANCREATIC ...)
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[[Image:1oa6.gif|left|200px]]<br /><applet load="1oa6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oa6" />
 
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'''THE SOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT HIGH PRESSURE'''<br />
 
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==Overview==
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==The solution structure of bovine pancreatic trypsin inhibitor at high pressure==
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The solution structure of bovine pancreatic trypsin inhibitor (BPTI) at a, pressure of 2 kbar is presented. The structure was calculated as a change, from an energy-minimized low-pressure structure, using (1)H chemical, shifts as restraints. The structure has changed by 0.24 A RMS, and has, almost unchanged volume. The largest changes as a result of pressure are, in the loop 10-16, which contains the active site of BPTI, and residues, 38-42, which are adjacent to buried water molecules. Hydrogen bonds are, compressed by 0.029 +/- 0.117 A, with the longer hydrogen bonds, including, those to internal buried water molecules, being compressed more. The, hydrophobic core is also compressed, largely from reduction of packing, defects. The parts of the structure that have the greatest change are, close to buried water molecules, thus highlighting the importance of water, molecules as the nucleation sites for volume fluctuation of proteins in, native conditions.
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<StructureSection load='1oa6' size='340' side='right'caption='[[1oa6]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1oa6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OA6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oa6 OCA], [https://pdbe.org/1oa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oa6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oa6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oa6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oa6 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1OA6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OA6 OCA].
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*[[BPTI 3D structures|BPTI 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The solution structure of bovine pancreatic trypsin inhibitor at high pressure., Williamson MP, Akasaka K, Refaee M, Protein Sci. 2003 Sep;12(9):1971-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12930996 12930996]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Akasaka, K.]]
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[[Category: Akasaka K]]
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[[Category: Refaee, M.]]
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[[Category: Refaee M]]
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[[Category: Williamson, M.P.]]
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[[Category: Williamson MP]]
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[[Category: protease inhibitor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:53:15 2007''
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Current revision

The solution structure of bovine pancreatic trypsin inhibitor at high pressure

PDB ID 1oa6

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