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1rlr

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[[Image:1rlr.jpg|left|200px]]
[[Image:1rlr.jpg|left|200px]]
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{{Structure
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|PDB= 1rlr |SIZE=350|CAPTION= <scene name='initialview01'>1rlr</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1rlr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
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{{STRUCTURE_1rlr| PDB=1rlr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rlr OCA], [http://www.ebi.ac.uk/pdbsum/1rlr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rlr RCSB]</span>
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'''STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1'''
'''STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1'''
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[[Category: Eklund, H.]]
[[Category: Eklund, H.]]
[[Category: Uhlin, U.]]
[[Category: Uhlin, U.]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: reductase (acting on ch2)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:39:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:29:56 2008''
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Revision as of 04:39, 3 May 2008

Image:1rlr.jpg

Template:STRUCTURE 1rlr

STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1


Overview

Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction.

About this Structure

1RLR is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of ribonucleotide reductase protein R1., Uhlin U, Eklund H, Nature. 1994 Aug 18;370(6490):533-9. PMID:8052308 Page seeded by OCA on Sat May 3 07:39:09 2008

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