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8sgn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine== | |
| - | + | <StructureSection load='8sgn' size='340' side='right'caption='[[8sgn]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8sgn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8] and [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SGN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sgn OCA], [https://pdbe.org/8sgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sgn RCSB], [https://www.ebi.ac.uk/pdbsum/8sgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sgn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GP350_EBVB9 GP350_EBVB9] Initiates virion attachment to host B-lymphocyte cell, leading to virus entry. Acts by binding to host CR2 at the surface of B-lymphocytes, facilitating the binding of viral glycoprotein gp42 to HLA class II molecules. Attachment triggers virion-host membrane fusion and invasion of the host cell. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human herpesvirus 4 strain B95-8]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Macaca fascicularis]] | ||
| + | [[Category: Chen WH]] | ||
| + | [[Category: Jensen JL]] | ||
| + | [[Category: Joyce MG]] | ||
| + | [[Category: Kanekiyo M]] | ||
Current revision
Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine
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