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3epd

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{{Seed}}
 
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[[Image:3epd.png|left|200px]]
 
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<!--
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==CryoEM structure of poliovirus receptor bound to poliovirus type 3==
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The line below this paragraph, containing "STRUCTURE_3epd", creates the "Structure Box" on the page.
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<SX load='3epd' size='340' side='right' viewer='molstar' caption='[[3epd]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3epd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_poliovirus_3 Human poliovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
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{{STRUCTURE_3epd| PDB=3epd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epd OCA], [https://pdbe.org/3epd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epd RCSB], [https://www.ebi.ac.uk/pdbsum/3epd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epd ProSAT]</span></td></tr>
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</table>
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===CryoEM structure of poliovirus receptor bound to poliovirus type 3===
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== Function ==
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[https://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19011098}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19011098 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epd_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19011098}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3EPD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_poliovirus_3 Human poliovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPD OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epd ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses., Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG, Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18284-9. Epub 2008 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19011098 19011098]
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<references/>
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__TOC__
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</SX>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human poliovirus 3]]
[[Category: Human poliovirus 3]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Bator CM]]
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[[Category: Alternative splicing]]
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[[Category: Bowman VD]]
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[[Category: Cd155 structure immunoglobulin superfamily]]
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[[Category: Hafenstein S]]
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[[Category: Cell adhesion]]
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[[Category: Morais MC]]
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[[Category: Cell membrane]]
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[[Category: Mueller S]]
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[[Category: Glycoprotein]]
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[[Category: Rossmann MG]]
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[[Category: Host-virus interaction]]
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[[Category: Wimmer E]]
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[[Category: Immunoglobulin domain]]
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[[Category: Zhang P]]
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[[Category: Membrane]]
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[[Category: Poliovirus capsid jelly role]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 3 20:17:53 2008''
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Current revision

CryoEM structure of poliovirus receptor bound to poliovirus type 3

3epd, resolution 9.00Å

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OCA

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