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1oht

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[[Image:1oht.gif|left|200px]]<br />
 
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<applet load="1oht" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oht, resolution 2.0&Aring;" />
 
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'''PEPTIDOGLYCAN RECOGNITION PROTEIN-LB'''<br />
 
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==Overview==
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==Peptidoglycan recognition protein LB==
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The family of peptidoglycan recognition proteins (PGRPs) are associated, with the recognition of the peptidoglycan of microbes and subsequent, activation of signaling pathways for immune response. Here the crystal, structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and, shows an active-site cleft with a zinc cage. Poor conservation of surface, residues at the cleft predicts a widely varying individual specificity of, PGRPs for molecular patterns on microbial cell walls. At the back of this, cleft is a putatively conserved distinctive groove. The location and, mainly hydrophobic nature of the groove indicate that the back face serves, for subsequent signaling after clustering of PGRP molecules by binding to, polymeric cell wall components.
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<StructureSection load='1oht' size='340' side='right'caption='[[1oht]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1oht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OHT FirstGlance]. <br>
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1OHT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]] with ZN, EDO and TLA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OHT OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oht OCA], [https://pdbe.org/1oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oht RCSB], [https://www.ebi.ac.uk/pdbsum/1oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oht ProSAT]</span></td></tr>
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Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12845326 12845326]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGPLB_DROME PGPLB_DROME] N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.<ref>PMID:12845326</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/1oht_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oht ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Byun, M.]]
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[[Category: Byun M]]
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[[Category: Kim, M.S.]]
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[[Category: Kim M-S]]
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[[Category: Oh, B.H.]]
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[[Category: Oh B-H]]
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[[Category: EDO]]
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[[Category: TLA]]
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[[Category: ZN]]
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[[Category: hydrolase]]
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[[Category: peptidoglycan-recognition protein-lb isoform 2]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:07:47 2007''
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Current revision

Peptidoglycan recognition protein LB

PDB ID 1oht

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