This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ohw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:47, 17 April 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ohw.png|left|200px]]
 
-
<!--
+
==4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-vinyl GABA==
-
The line below this paragraph, containing "STRUCTURE_1ohw", creates the "Structure Box" on the page.
+
<StructureSection load='1ohw' size='340' side='right'caption='[[1ohw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ohw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OHW FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=VIG:4-AMINO+HEXANOIC+ACID'>VIG</scene></td></tr>
-
{{STRUCTURE_1ohw| PDB=1ohw | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ohw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ohw OCA], [https://pdbe.org/1ohw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ohw RCSB], [https://www.ebi.ac.uk/pdbsum/1ohw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ohw ProSAT]</span></td></tr>
-
 
+
</table>
-
===4-AMINOBUTYRATE-AMINOTRANSFERASE INACTIVATED BY GAMMA-VINYL GABA===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/GABT_PIG GABT_PIG] Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_14534310}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 14534310 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/1ohw_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_14534310}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1OHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHW OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ohw ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin., Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T, J Biol Chem. 2004 Jan 2;279(1):363-73. Epub 2003 Oct 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14534310 14534310]
+
</StructureSection>
-
[[Category: 4-aminobutyrate transaminase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
-
[[Category: Schirmer, T.]]
+
[[Category: Schirmer T]]
-
[[Category: Storici, P.]]
+
[[Category: Storici P]]
-
[[Category: 4-aminobutyric acid]]
+
-
[[Category: Aminotransferase]]
+
-
[[Category: Antiepileptic drug target]]
+
-
[[Category: Mitochondrion]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Plp-dependent enzyme]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transit peptide]]
+
-
[[Category: Vigabatrin pyridoxal phosphate]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:04:31 2008''
+

Current revision

4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-vinyl GABA

PDB ID 1ohw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ohw"
Personal tools