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1omx

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{{Seed}}
 
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[[Image:1omx.png|left|200px]]
 
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==Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2)==
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The line below this paragraph, containing "STRUCTURE_1omx", creates the "Structure Box" on the page.
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<StructureSection load='1omx' size='340' side='right'caption='[[1omx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1omx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OMX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_1omx| PDB=1omx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1omx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omx OCA], [https://pdbe.org/1omx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1omx RCSB], [https://www.ebi.ac.uk/pdbsum/1omx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1omx ProSAT]</span></td></tr>
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</table>
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===Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2)===
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== Function ==
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[https://www.uniprot.org/uniprot/EXTL2_MOUSE EXTL2_MOUSE] Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (By similarity).
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12562774}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12562774 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/1omx_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12562774}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1OMX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMX OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1omx ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis., Pedersen LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen LG, Sugahara K, Negishi M, J Biol Chem. 2003 Apr 18;278(16):14420-8. Epub 2003 Jan 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12562774 12562774]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Dong J]]
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[[Category: Dong, J.]]
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[[Category: Kitagawa H]]
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[[Category: Kitagawa, H.]]
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[[Category: Krahn JM]]
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[[Category: Krahn, J M.]]
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[[Category: Negishi M]]
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[[Category: Negishi, M.]]
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[[Category: Pedersen LC]]
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[[Category: Pedersen, L C.]]
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[[Category: Pedersen LG]]
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[[Category: Pedersen, L G.]]
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[[Category: Sugahara K]]
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[[Category: Sugahara, K.]]
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[[Category: Taniguchi F]]
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[[Category: Taniguchi, F.]]
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[[Category: Dxd motif]]
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[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:11:37 2008''
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Current revision

Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2)

PDB ID 1omx

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