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1onj
From Proteopedia
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| - | [[Image:1onj.png|left|200px]] | ||
| - | + | ==Crystal structure of Atratoxin-b from Chinese cobra venom of Naja atra== | |
| - | + | <StructureSection load='1onj' size='340' side='right'caption='[[1onj]], [[Resolution|resolution]] 1.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1onj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.555Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onj OCA], [https://pdbe.org/1onj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onj RCSB], [https://www.ebi.ac.uk/pdbsum/1onj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onj ProSAT]</span></td></tr> |
| - | [[1onj]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/3S1CC_NAJAT 3S1CC_NAJAT] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Has a lower toxicity than cobrotoxin.<ref>PMID:9498573</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1onj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
| - | [[Category: Deng | + | [[Category: Deng W]] |
| - | [[Category: Fan | + | [[Category: Fan R]] |
| - | [[Category: Lou | + | [[Category: Lou X]] |
| - | [[Category: Lu | + | [[Category: Lu W]] |
| - | [[Category: Niu | + | [[Category: Niu L]] |
| - | [[Category: Pan | + | [[Category: Pan G]] |
| - | [[Category: Rao | + | [[Category: Rao P]] |
| - | [[Category: Teng | + | [[Category: Teng M]] |
| - | [[Category: Tu | + | [[Category: Tu X]] |
| - | [[Category: Xu | + | [[Category: Xu C]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Atratoxin-b from Chinese cobra venom of Naja atra
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