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1org

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[[Image:1org.gif|left|200px]]
 
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==The crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae reveals a new mechanism of pheromone binding==
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The line below this paragraph, containing "STRUCTURE_1org", creates the "Structure Box" on the page.
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<StructureSection load='1org' size='340' side='right'caption='[[1org]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1org]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhyparobia_maderae Rhyparobia maderae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1org| PDB=1org | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1org FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1org OCA], [https://pdbe.org/1org PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1org RCSB], [https://www.ebi.ac.uk/pdbsum/1org PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1org ProSAT]</span></td></tr>
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</table>
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'''The crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae reveals a new mechanism of pheromone binding'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q8MTC1_RHYMA Q8MTC1_RHYMA]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Pheromone-binding proteins (PBPs) are small helical proteins found in sensorial organs, particularly in the antennae, of moth and other insect species. They were proposed to solubilize and carry the hydrophobic pheromonal compounds through the antennal lymph to receptors, participating thus in the peri-receptor events of signal transduction. The x-ray structure of Bombyx mori PBP (BmorPBP), from male antennae, revealed a six-helix fold forming a cavity that contains the pheromone bombykol. We have identified a PBP (LmaPBP) from the cockroach Leucophaea maderae in the antennae of the females, the gender attracted by pheromones in this species. Here we report the crystal structure of LmaPBP alone or in complex with a fluorescent reporter (amino-naphthalen sulfonate, ANS) or with a component of the pheromonal blend, 3-hydroxy-butan-2-one. Both compounds bind in the internal cavity of LmaPBP, which is more hydrophilic than BmorPBP cavity. LmaPBP structure ends just after the sixth helix (helix F). BmorPBP structure extends beyond the sixth helix with a stretch of residues elongated at neutral pH and folding as a seventh internalized helix at low pH. These differences between LmaPBP and BmorPBP structures suggest that different binding and release mechanism may be adapted to the hydrophilicity or hydrophobicity of the pheromonal ligand.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1org_consurf.spt"</scriptWhenChecked>
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1ORG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leucophaea_maderae Leucophaea maderae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORG OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The crystal structure of a cockroach pheromone-binding protein suggests a new ligand binding and release mechanism., Lartigue A, Gruez A, Spinelli S, Riviere S, Brossut R, Tegoni M, Cambillau C, J Biol Chem. 2003 Aug 8;278(32):30213-8. Epub 2003 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12766173 12766173]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1org ConSurf].
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[[Category: Leucophaea maderae]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Brossut, R.]]
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</StructureSection>
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[[Category: Cambillau, C.]]
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[[Category: Large Structures]]
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[[Category: Gruez, A.]]
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[[Category: Rhyparobia maderae]]
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[[Category: Lartigue, A.]]
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[[Category: Brossut R]]
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[[Category: Riviere, S.]]
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[[Category: Cambillau C]]
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[[Category: Spinelli, S.]]
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[[Category: Gruez A]]
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[[Category: Tegoni, M.]]
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[[Category: Lartigue A]]
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[[Category: 6 alpha helix]]
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[[Category: Riviere S]]
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[[Category: Apo-form]]
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[[Category: Spinelli S]]
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[[Category: Pheromone binding protein]]
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[[Category: Tegoni M]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:11:34 2008''
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Current revision

The crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae reveals a new mechanism of pheromone binding

PDB ID 1org

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