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1orl

From Proteopedia

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(New page: 200px<br /><applet load="1orl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1orl" /> '''1H NMR structure determination of Viscotoxin...)
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[[Image:1orl.jpg|left|200px]]<br /><applet load="1orl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1orl" />
 
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'''1H NMR structure determination of Viscotoxin C1'''<br />
 
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==Overview==
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==1H NMR structure determination of Viscotoxin C1==
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The high resolution three-dimensional structure of the newly discovered, plant viscotoxin C1, from the Asiatic Viscum album ssp. Coloratum ohwi, has been determined in solution by (1)H NMR spectroscopy at pH 3.6 and 285, K. The viscotoxin C1-fold, consisting of a helix-turn-helix motif and a, short stretch of an antiparralel beta-sheet is very similar to that found, for the highly similar viscotoxins A2 and A3 and for other related, thionins. Different functional properties of members of the thionin family, are discussed here in light of the structural and electrostatic, properties. Among the very homologous family of alpha- and beta-thionins, known for their antimicrobial activity, the viscotoxin subfamily differs, from the other members because of its high toxicity against tumoral cells., Key residues for the modulation of viscotoxin cytotoxicity have been, identified on the basis of sequence and structural alignment.
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<StructureSection load='1orl' size='340' side='right'caption='[[1orl]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
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1ORL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [https://pdbe.org/1orl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [https://www.ebi.ac.uk/pdbsum/1orl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
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==Reference==
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</table>
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NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins., Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H, Biochemistry. 2003 Nov 4;42(43):12503-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14580196 14580196]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/THNC_VISAL THNC_VISAL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1orl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1orl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: Catalano, M.]]
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[[Category: Catalano M]]
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[[Category: Fogolari, F.]]
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[[Category: Fogolari F]]
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[[Category: Giannattasio, M.]]
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[[Category: Giannattasio M]]
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[[Category: Molinari, H.]]
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[[Category: Molinari H]]
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[[Category: Ragona, L.]]
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[[Category: Ragona L]]
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[[Category: Romagnoli, S.]]
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[[Category: Romagnoli S]]
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[[Category: Urech, K.]]
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[[Category: Urech K]]
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[[Category: beta-sheet]]
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[[Category: concentric motif of disulphide bridges]]
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[[Category: helix-turn-helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:07:51 2007''
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Current revision

1H NMR structure determination of Viscotoxin C1

PDB ID 1orl

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