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1os6

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[[Image:1os6.jpg|left|200px]]
 
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{{Structure
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==Cytochrome c7 (PpcA) from Geobacter sulfurreducens==
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|PDB= 1os6 |SIZE=350|CAPTION= <scene name='initialview01'>1os6</scene>, resolution 1.45&Aring;
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<StructureSection load='1os6' size='340' side='right'caption='[[1os6]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=DXC:(3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID'>DXC</scene>
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<table><tr><td colspan='2'>[[1os6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OS6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1os6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os6 OCA], [https://pdbe.org/1os6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1os6 RCSB], [https://www.ebi.ac.uk/pdbsum/1os6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1os6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8GGK7_GEOSN Q8GGK7_GEOSN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1os6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1os6 ConSurf].
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<div style="clear:both"></div>
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'''Cytochrome c7 (PpcA) from Geobacter sulfurreducens'''
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==See Also==
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*[[Art:Cytochrome Wallpaper|Art:Cytochrome Wallpaper]]
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__TOC__
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==Overview==
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</StructureSection>
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The structure of a cytochrome c(7) (PpcA) from Geobacter sulfurreducens was determined by X-ray diffraction at 1.45 A resolution; the R factor is 18.2%. The protein contains a three-heme core that is surrounded by 71 amino acid residues. An unusual feature of this cytochrome is that it has 17 lysine residues, but only nine hydrophobic residues that are larger than alanine. The details of the structure are described and compared with those of cytochrome c(7) from Desulfuromonas acetoxidans and with cytochromes c(3). The two cytochrome c(7) molecules have sequences that are 46% identical, but the arrangements of the hemes in the two structures differ; the rms deviation of all alpha-carbons is 2.5 A. These cytochromes can reduce various metal ions. The reduction site of the chromate ion in D. acetoxidans is occupied by a sulfate ion in the crystal structure of PpcA. We identified four additional homologues of cytochrome c(7) in the G. sulfurreducens genome and three polymers of c(7)-type domains. Of the polymers, two have four repeats and one has nine repeats. On the basis of sequence alignments, one of the hemes in each of the cytochrome c(7)-type domains does not have the bis-histidine coordination. The packing of the molecules in the crystal structure of PpcA suggests that the polymers have an elongated conformation and might form a "nanowire".
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==About this Structure==
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1OS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS6 OCA].
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==Reference==
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Family of cytochrome c7-type proteins from Geobacter sulfurreducens: structure of one cytochrome c7 at 1.45 A resolution., Pokkuluri PR, Londer YY, Duke NE, Long WC, Schiffer M, Biochemistry. 2004 Feb 3;43(4):849-59. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14744127 14744127]
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[[Category: Geobacter sulfurreducens]]
[[Category: Geobacter sulfurreducens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Duke, N E.C.]]
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[[Category: Duke NEC]]
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[[Category: Londer, Y Y.]]
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[[Category: Londer YY]]
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[[Category: Long, W C.]]
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[[Category: Long WC]]
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[[Category: Pokkuluri, P R.]]
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[[Category: Pokkuluri PR]]
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[[Category: Schiffer, M.]]
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[[Category: Schiffer M]]
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[[Category: DXC]]
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[[Category: HEM]]
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[[Category: SO4]]
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[[Category: mutli-heme cytochrome]]
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[[Category: ppca]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:14:54 2008''
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Current revision

Cytochrome c7 (PpcA) from Geobacter sulfurreducens

PDB ID 1os6

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