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1ouu

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[[Image:1ouu.jpg|left|200px]]
 
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{{Structure
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==CARBONMONOXY TROUT HEMOGLOBIN I==
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|PDB= 1ouu |SIZE=350|CAPTION= <scene name='initialview01'>1ouu</scene>, resolution 2.5&Aring;
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<StructureSection load='1ouu' size='340' side='right'caption='[[1ouu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=CMO:CARBON MONOXIDE'>CMO</scene>
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<table><tr><td colspan='2'>[[1ouu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OUU FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ouu OCA], [https://pdbe.org/1ouu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ouu RCSB], [https://www.ebi.ac.uk/pdbsum/1ouu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ouu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBA1_ONCMY HBA1_ONCMY] Involved in oxygen transport from gills to the various peripheral tissues.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/1ouu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ouu ConSurf].
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<div style="clear:both"></div>
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'''CARBONMONOXY TROUT HEMOGLOBIN I'''
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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We have determined the X-ray crystallographic structure of trout Hb I in both the deoxy and carbonmonoxy forms to resolution limits of 2.3 angstroms and 2.5 angstroms, respectively. The overall fold of the molecule is highly similar to that of human HbA despite the low level of sequence identity between these proteins. Trout Hb I is unusual in displaying almost no pH dependence of oxygen binding affinity, and (at most) very weak interactions with heterotropic effector ligands such as organic phosphates. Comparison of the two quaternary states of the protein indicates how such effects are minimised and how the low-affinity T state of the protein is stabilised in the absence of heterotropic interactions.
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[[Category: Large Structures]]
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==About this Structure==
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1OUU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUU OCA].
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==Reference==
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The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms., Tame JR, Wilson JC, Weber RE, J Mol Biol. 1996 Jun 21;259(4):749-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8683580 8683580]
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[[Category: Oncorhynchus mykiss]]
[[Category: Oncorhynchus mykiss]]
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[[Category: Protein complex]]
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[[Category: Tame J]]
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[[Category: Tame, J.]]
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[[Category: Wilson J]]
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[[Category: Wilson, J.]]
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[[Category: ACE]]
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[[Category: CMO]]
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[[Category: HEM]]
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[[Category: erythrocyte]]
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[[Category: heme]]
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[[Category: oxygen transport]]
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[[Category: respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:59 2008''
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Current revision

CARBONMONOXY TROUT HEMOGLOBIN I

PDB ID 1ouu

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