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1p5y

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{{Seed}}
 
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[[Image:1p5y.png|left|200px]]
 
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==The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants==
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The line below this paragraph, containing "STRUCTURE_1p5y", creates the "Structure Box" on the page.
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<StructureSection load='1p5y' size='340' side='right'caption='[[1p5y]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P5Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p5y OCA], [https://pdbe.org/1p5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p5y RCSB], [https://www.ebi.ac.uk/pdbsum/1p5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p5y ProSAT]</span></td></tr>
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{{STRUCTURE_1p5y| PDB=1p5y | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_PAVCD CAPSD_PAVCD] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptor TFRC. This attachment induces virion internalization predominantly through clathrin-endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell (By similarity). Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids.<ref>PMID:11799183</ref> <ref>PMID:12970411</ref> <ref>PMID:19656887</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/1p5y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p5y ConSurf].
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<div style="clear:both"></div>
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===The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants===
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==See Also==
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*[[Canine parvovirus|Canine parvovirus]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_14581558}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 14581558 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_14581558}}
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==About this Structure==
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1P5Y is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5Y OCA].
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==Reference==
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<ref group="xtra">PMID:14581558</ref><references group="xtra"/>
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[[Category: Canine parvovirus]]
[[Category: Canine parvovirus]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Large Structures]]
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[[Category: Govindasamy, L.]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Cpv]]
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[[Category: Govindasamy L]]
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[[Category: Fpv]]
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[[Category: Icosahedral virus]]
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[[Category: Parvovirade]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:40:47 2009''
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Current revision

The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants

PDB ID 1p5y

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