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1p9k

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[[Image:1p9k.gif|left|200px]]
 
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{{Structure
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==THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING==
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|PDB= 1p9k |SIZE=350|CAPTION= <scene name='initialview01'>1p9k</scene>
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<StructureSection load='1p9k' size='340' side='right'caption='[[1p9k]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1p9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1o09 1o09]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9K FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= ybcJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9k OCA], [https://pdbe.org/1p9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9k RCSB], [https://www.ebi.ac.uk/pdbsum/1p9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9k ProSAT], [https://www.topsan.org/Proteins/BSGI/1p9k TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9k OCA], [http://www.ebi.ac.uk/pdbsum/1p9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9k RCSB]</span>
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[https://www.uniprot.org/uniprot/YBCJ_ECOLI YBCJ_ECOLI] Its structure and the presence of conserved basic residues indicates that it probably binds RNA.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9k_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The structure of the recombinant Escherichia coli protein YbcJ, a representative of a conserved family of bacterial proteins (COG2501), was determined by nuclear magnetic resonance. The fold of YbcJ identified it as a member of the larger family of S4-like RNA binding domains. These domains bind to structured RNA, such as that found in tRNA, rRNA, and a pseudoknot of mRNA. The structure of YbcJ revealed a highly conserved patch of basic residues, comprising amino acids K26, K38, R55, K56, and K59, which likely participate in RNA binding.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p9k ConSurf].
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1P9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry 1O09. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9K OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The solution structure of YbcJ from Escherichia coli reveals a recently discovered alphaL motif involved in RNA binding., Volpon L, Lievre C, Osborne MJ, Gandhi S, Iannuzzi P, Larocque R, Cygler M, Gehring K, Ekiel I, J Bacteriol. 2003 Jul;185(14):4204-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837795 12837795]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cygler M]]
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[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
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[[Category: Ekiel I]]
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[[Category: Cygler, M.]]
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[[Category: Gandhi S]]
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[[Category: Ekiel, I.]]
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[[Category: Gehring K]]
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[[Category: Gandhi, S.]]
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[[Category: Iannuzzi P]]
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[[Category: Gehring, K.]]
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[[Category: Larocque R]]
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[[Category: Iannuzzi, P.]]
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[[Category: Lievre C]]
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[[Category: Larocque, R.]]
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[[Category: Matte A]]
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[[Category: Lievre, C.]]
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[[Category: Osborne MJ]]
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[[Category: Matte, A.]]
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[[Category: Volpon L]]
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[[Category: Osborne, M J.]]
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[[Category: Volpon, L.]]
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[[Category: alfal motif]]
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[[Category: bsgi]]
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[[Category: e coli]]
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[[Category: montreal-kingston bacterial structural genomics initiative]]
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[[Category: rna-binding protein]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:47 2008''
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Current revision

THE SOLUTION STRUCTURE OF YBCJ FROM E. COLI REVEALS A RECENTLY DISCOVERED ALFAL MOTIF INVOLVED IN RNA-BINDING

PDB ID 1p9k

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