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1pe3

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[[Image:1pe3.gif|left|200px]]
 
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{{Structure
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==Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)==
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|PDB= 1pe3 |SIZE=350|CAPTION= <scene name='initialview01'>1pe3</scene>
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<StructureSection load='1pe3' size='340' side='right'caption='[[1pe3]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1pe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PE3 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= TFF3 OR ITF OR TFI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe3 OCA], [https://pdbe.org/1pe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pe3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pe3 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)'''
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[https://www.uniprot.org/uniprot/TFF3_HUMAN TFF3_HUMAN] Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).<ref>PMID:11694446</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The trefoil protein TFF3 forms a homodimer (via a disulfide linkage) that is thought to have increased biological activity over the monomer. The solution structure of the TFF3 dimer has been determined by NMR and compared with the structure of the TFF3 monomer and with other trefoil dimer structures (TFF1 and TFF2). The most significant structural differences between the trefoil domain in the monomer and dimer TFF3 are in the orientations of the N-terminal 3(10)-helix (residues 10-12) and in the presence in the dimer of an additional 3(10)-helix (residues 53-55) outside of the core region. The TFF3 dimer forms a more compact structure as compared with the TFF1 dimer where the two trefoil domains are connected by a flexible region with the monomer units being at variable distances from each other and in many different orientations. Although TFF2 is also a compact structure, the dispositions of its monomer units are very different from those of TFF3. The structural differences between the dimers result in the two putative receptor/ligand binding sites that remain solvent exposed in the dimeric structures having very different dispositions in the different dimers. Such differences have significant implications for the mechanism of action and functional specificity for the TFF class of proteins.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1pe3_consurf.spt"</scriptWhenChecked>
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==Disease==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Known disease associated with this structure: Pitt-Hopkins syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602272 602272]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pe3 ConSurf].
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1PE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE3 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins., Muskett FW, May FE, Westley BR, Feeney J, Biochemistry. 2003 Dec 30;42(51):15139-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14690424 14690424]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Feeney, J.]]
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[[Category: Feeney J]]
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[[Category: May, F E.]]
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[[Category: May FE]]
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[[Category: Muskett, F W.]]
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[[Category: Muskett FW]]
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[[Category: Westley, B R.]]
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[[Category: Westley BR]]
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[[Category: intestinal trefoil factor]]
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[[Category: itf]]
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[[Category: nmr spectroscopy]]
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[[Category: solution structure]]
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[[Category: tff3]]
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[[Category: tff3 dimer]]
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[[Category: trefoil factor family]]
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[[Category: trefoil motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:23:10 2008''
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Current revision

Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)

PDB ID 1pe3

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