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1ped

From Proteopedia

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[[Image:1ped.png|left|200px]]
 
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==BACTERIAL SECONDARY ALCOHOL DEHYDROGENASE (APO-FORM)==
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The line below this paragraph, containing "STRUCTURE_1ped", creates the "Structure Box" on the page.
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<StructureSection load='1ped' size='340' side='right'caption='[[1ped]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ped]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PED FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1ped| PDB=1ped | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ped FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ped OCA], [https://pdbe.org/1ped PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ped RCSB], [https://www.ebi.ac.uk/pdbsum/1ped PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ped ProSAT]</span></td></tr>
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</table>
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===BACTERIAL SECONDARY ALCOHOL DEHYDROGENASE (APO-FORM)===
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== Function ==
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[https://www.uniprot.org/uniprot/ADH_CLOBE ADH_CLOBE] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is active with acetaldehyde and propionaldehyde.<ref>PMID:8349550</ref> <ref>PMID:20102159</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15299659}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15299659 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1ped_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15299659}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1ped]] is a 4 chain structure of [[Alcohol dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PED OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ped ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
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*[[Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T. brockii ADH by E. histolytica ADH|Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T. brockii ADH by E. histolytica ADH]]
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*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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*[[Chimeres of alcohol dehydrogenases|Chimeres of alcohol dehydrogenases]]
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== References ==
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*[[Tetrameric alcohol dehydrogenases|Tetrameric alcohol dehydrogenases]]
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015299659</ref><references group="xtra"/>
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[[Category: Clostridium beijerinckii]]
[[Category: Clostridium beijerinckii]]
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[[Category: Frolow, F.]]
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[[Category: Large Structures]]
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[[Category: Korkhin, Y.]]
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[[Category: Frolow F]]
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[[Category: Nadp]]
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[[Category: Korkhin Y]]
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[[Category: Oxidoreductase]]
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[[Category: Thermostable]]
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Current revision

BACTERIAL SECONDARY ALCOHOL DEHYDROGENASE (APO-FORM)

PDB ID 1ped

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