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1pfb

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{{Seed}}
 
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[[Image:1pfb.png|left|200px]]
 
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==Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27==
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The line below this paragraph, containing "STRUCTURE_1pfb", creates the "Structure Box" on the page.
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<StructureSection load='1pfb' size='340' side='right'caption='[[1pfb]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PFB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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{{STRUCTURE_1pfb| PDB=1pfb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pfb OCA], [https://pdbe.org/1pfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pfb RCSB], [https://www.ebi.ac.uk/pdbsum/1pfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pfb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PC_DROME PC_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specific chromatin compaction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/1pfb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pfb ConSurf].
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<div style="clear:both"></div>
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===Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27===
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_12897052}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 12897052 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_12897052}}
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==About this Structure==
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1PFB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFB OCA].
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==Reference==
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<ref group="xtra">PMID:12897052</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Min, J R.]]
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[[Category: Large Structures]]
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[[Category: Xu, R M.]]
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[[Category: Strongylocentrotus purpuratus]]
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[[Category: Zhang, Y.]]
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[[Category: Min JR]]
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[[Category: Chromatin]]
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[[Category: Xu R-M]]
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[[Category: Chromodomain]]
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[[Category: Zhang Y]]
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[[Category: Histone methylation]]
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[[Category: Polycomb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:36:11 2009''
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Current revision

Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27

PDB ID 1pfb

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