1pip

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[[Image:1pip.png|left|200px]]
 
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{{STRUCTURE_1pip| PDB=1pip | SCENE= }}
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==CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS==
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<StructureSection load='1pip' size='340' side='right'caption='[[1pip]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_1445868}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pip OCA], [https://pdbe.org/1pip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pip RCSB], [https://www.ebi.ac.uk/pdbsum/1pip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pip ProSAT]</span></td></tr>
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[[1pip]] is a 2 chain structure of [[Papain]] with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAPA1_CARPA PAPA1_CARPA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1pip_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pip ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Papain|Papain]]
*[[Papain|Papain]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:001445868</ref><ref group="xtra">PMID:009048550</ref><references group="xtra"/>
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[[Category: Carica papaya]]
[[Category: Carica papaya]]
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[[Category: Papain]]
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[[Category: Large Structures]]
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[[Category: Doi, M.]]
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[[Category: Doi M]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Ishida, T.]]
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[[Category: Ishida T]]
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[[Category: Ohishi, H.]]
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[[Category: Ohishi H]]
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[[Category: Okada, Y.]]
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[[Category: Okada Y]]
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[[Category: Okamoto, H.]]
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[[Category: Okamoto H]]
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[[Category: Tomoo, K.]]
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[[Category: Tomoo K]]
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[[Category: Tsuboi, S.]]
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[[Category: Tsuboi S]]
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[[Category: Yamamoto, A.]]
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[[Category: Yamamoto A]]
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[[Category: Yamamoto, D.]]
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[[Category: Yamamoto D]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Thiol protease]]
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Current revision

CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS

PDB ID 1pip

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OCA

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